Prognostic factors in chronic lymphocytic leukemia
نویسندگان
چکیده
منابع مشابه
Prognostic factors in chronic lymphocytic leukemia.
The Rai staging system is widely used and is easy to apply in clinical practice. The system introduced by Binet et al offers an advantage that it consists only of three stages and, therefore, is more practical for initiation of controlled therapeutic trials than the five-stage Rai system. However, when we take into consideration the survival curves, it is important to note that the Rai system h...
متن کاملChronic lymphocytic leukemia and prognostic factors.
BACKGROUND The clinical course of individual chronic lymphocytic leukemia (CLL) is highly variable and clinical staging systems do not help us to predict if and at what rate there will be disease progression in an individual patient diagnosed with early stage disease. Recently, several important observations related to other prognostic factors including lymphocyte doubling time (LDT), β2-microg...
متن کاملMultivariate analysis of prognostic factors in chronic lymphocytic leukemia.
Prognostic factors in a group of 90 patients with chronic lymphocytic leukemia were studied by methods of survival analysis. The relationship between survival and a set of demographic, clinical and laboratory variables, and identification of subsets of variables that are associated with survival, was tested by multivariate analysis, which is based upon Cox proportional hazards regression models...
متن کاملCHRONIC LYMPHOCYTIC LEUKEMIA Biology and prognostic factors in CLL
The immunoglobulin heavy and light chain genes which encode the antigen binding site of the B cell receptor (BCR) in CLL may be either mutated or unmutated raising the question as to whether CLL originates from a single, or more than one target cell. Microarray studies performed to address this issue have been inconclusive but do show a common ‘‘CLL signature’’ quite similar to that of both nor...
متن کاملDicer Gene Expression as a Prognostic Factor in Acute Lymphoblastic Leukemia and Chronic Lymphocytic Leukemia in Fars Province
Alterations in the expression of microRNAs (miRNAs) have been proposed to play a role in the pathogenesis of acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL). Dicer is one of the main regulators of miRNA biogenesis, and deregulation of its expression has been indicated as a possible cause of miRNA alterations observed in various cancers. Our aim was to analyze the expre...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2008
ISSN: 0923-7534
DOI: 10.1093/annonc/mdn196